Campuses: Twin Cities | Crookston | Duluth | Morris | Rochester | Other Locations


Home > Biosafety > Biosafety Manual > Select Agents > Federal Select Agent List & Toxin Exemptions

Federal Select Agents & Toxins List and Exemptions

Does your lab possess any of the agents or toxins listed here? If so, determine which set of procedures you must follow.

Labs possessing select agent toxin quantities in excess of the amounts listed below or any other select agent are subject to federal select agent registration and regulations and must follow the University's Procedures for Labs Working with Federally Regulated Select Agents.

Toxin quantities, per principal investigator, not exceeding the amounts shown below are exempt from federal select agent registration and regulations. However, labs using or possessing federally exempt quantities of select agent toxins must follow the University's Procedures for Labs Working with Federally Exempt Quantities of Select Agents.

For additional exemptions, see CDC's Select Agent Program Notification of Exclusion.

HHS SELECT AGENTS AND TOXINS

Abrin (100 mg)
Botulinum neurotoxins* (0.5 mg)
Botulinum neurotoxin producing species of Clostridium*
Conotoxins (Short, paralytic alpha conotoxins containing the following amino acid sequence X1CCX2PACGX3X4X5X6CX7)1 (100 mg)
Coxiella burnetii
Crimean-Congo haemorrhagic fever virus
Diacetoxyscirpenol (1000 mg)
Eastern Equine Encephalitis virus3
Ebola virus*
Francisella tularensis*
Lassa fever virus
Lujo virus
Marburg virus*
Monkeypox virus3
Reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 Influenza virus)
Ricin (100 mg)
Rickettsia prowazekii
SARS-associated coronavirus (SARS-CoV)
Saxitoxin (100 mg)
South American Haemorrhagic Fever viruses:

Staphylococcal enterotoxins A,B,C,D,E subtypes (5.0 mg)
T-2 toxin (1000 mg)
Tetrodotoxin (100 mg)
Tick-borne encephalitis complex (flavi) viruses:

  • Far Eastern subtype
  • Siberian subtype

Kyasanur Forest disease virus
Omsk hemorrhagic fever virus
Variola major virus (Smallpox virus)*
Variola minor virus (Alastrim)*
Yersinia pestis*

 

OVERLAP SELECT AGENTS AND TOXINS

Bacillus anthracis*
Bacillus anthracis Pasteur strain
Brucella abortus
Brucella melitensis
Brucella suis
Burkholderia mallei*
Burkholderia pseudomallei*
Hendra virus
Nipah virus
Rift Valley fever virus
Venezuelan equine encephalitis virus3

USDA SELECT AGENTS AND TOXINS

African horse sickness virus
African swine fever virus
Avian influenza virus3
Classical swine fever virus
Foot-and-mouth disease virus*
Goat pox virus
Lumpy skin disease virus
Mycoplasma capricolum3
Mycoplasma mycoides3
Newcastle disease virus2,3
Peste des petits ruminants virus
Rinderpest virus*
Sheep pox virus
Swine vesicular disease virus

USDA PLANT PROTECTION AND QUARANTINE (PPQ) SELECT AGENTS AND TOXINS

Peronosclerospora philippinensis
  (Peronosclerospora sacchari)

Phoma glycinicola (formerly Pyrenochaeta glycines)
Ralstonia solanacearum
Rathayibacter toxicus
Sclerophthora rayssiae
Synchytrium endobioticum
Xanthomonas oryzae

*Denotes Tier 1 Agent

1 C = Cysteine residues are all present as disulfides, with the 1st and 3rd Cysteine, and the 2nd and 4th Cysteine forming specific disulfide bridges; The consensus sequence includes known toxins α-MI and α-GI (shown above) as well as α-GIA, Ac1.1a, α-CnIA, α-CnIB; X1 = any amino acid(s) or Des-X; X2 = Asparagine or Histidine; P = Proline;  A = Alanine;  G = Glycine; X3 = Arginine or Lysine;  X4 = Asparagine, Histidine, Lysine, Arginine, Tyrosine, Phenylalanine or Tryptophan; X5 = Tyrosine, Phenylalanine, or Tryptophan;  X6 = Serine, Threonine, Glutamate, Aspartate, Glutamine, or Asparagine;  X7 = Any amino acid(s) or Des X and; “Des X” = “an amino acid does not have to be present at this position.”  For example if a peptide sequence were XCCHPA then the related peptide CCHPA would be designated as Des-X.

2 A virulent Newcastle disease virus (avian paramyxovirus serotype 1) has an intracerebral pathogenicity index in day-old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus.  A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus.

3 Select agents that meet any of the following criteria are excluded from the requirements of this part: Any low pathogenic strains of avian influenza virus, South American genotype of eastern equine encephalitis virus , west African clade of Monkeypox viruses, any strain of Newcastle disease virus which does not meet the criteria for virulent Newcastle disease virus, all subspecies Mycoplasma capricolum except subspecies capripneumoniae (contagious caprine pleuropneumonia), all subspecies Mycoplasma mycoides except subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia), and any subtypes of Venezuelan equine encephalitis virus except for Subtypes IAB or IC, provided that the individual or entity can verify that the agent is within the exclusion category. 9/10/13

SELECT AGENTS AND TOXINS EXCLUSIONS

Attenuated strains of HHS Select Agents and Toxins excluded

Attenuated strains of Overlap Select Agents excluded Attenuated strains of USDA-only select agents excluded

Top of Page