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Federal Select Agent List & Toxin Exemptions

Does your lab possess any of the agents or toxins listed here? If so, determine which set of procedures you must follow.

Labs possessing select agent toxin quantities in excess of the amounts listed below or any other select agent are subject to federal select agent registration and regulations and must follow the University's Procedures for Labs Working with Federally Regulated Select Agents.

Toxin quantities, per principal investigator, not exceeding the amounts shown below are exempt from federal select agent registration and regulations. However, labs using or possessing federally exempt quantities of select agent toxins must follow the University's Procedures for Labs Working with Federally Exempt Quantities of Select Agents.

For additional exemptions, see CDC's Select Agent Program Notification of Exclusion.

HHS SELECT AGENTS AND TOXINS

Abrin (100 mg)
Botulinum neurotoxins (0.5 mg)
Botulinum neurotoxin producing species of Clostridium
Cercopithecine herpesvirus 1 (Herpes B virus)
Clostridium perfringens epsilon toxin (100 mg)
Coccidioides posadasii/Coccidioides immitis
Conotoxins (100 mg)
Coxiella burnetii
Crimean-Congo haemorrhagic fever virus
Diacetoxyscirpenol (1000 mg)
Eastern Equine Encephalitis virus
Ebola virus
Francisella tularensis
Lassa fever virus
Marburg virus
Monkeypox virus
Reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 influenza virus)
Ricin (100 mg)
Rickettsia prowazekii
Rickettsia rickettsii
Saxitoxin (100 mg)
Shiga-like ribosome inactivating proteins (100 mg)
Shigatoxin (100 mg)
South American Haemorrhagic Fever viruses:

Staphylococcal enterotoxins (5.0 mg)
T-2 toxin (1000 mg)
Tetrodotoxin (100 mg)
Tick-borne encephalitis complex (flavi) viruses:

Variola major virus (Smallpox virus)
Variola minor virus (Alastrim)
Yersinia pestis
Note: red indicates the maximum exempt quantities of select agent toxins.

OVERLAP SELECT AGENTS AND TOXINS

Bacillus anthracis
Brucella abortus
Brucella melitensis
Brucella suis
Burkholderia mallei (formerly Pseudomonas mallei)
Burkholderia pseudomallei (formerly Pseudomonas pseudomallei)
Hendra virus
Nipah virus
Rift Valley fever virus
Venezuelan Equine Encephalitis virus

USDA SELECT AGENTS AND TOXINS

African horse sickness virus
African swine fever virus
Akabane virus
Avian influenza virus (highly pathogenic)
Bluetongue virus (exotic)
Bovine spongiform encephalopathy agent
Camel pox virus
Classical swine fever virus
Ehrlichia ruminantium (Heartwater)
Foot-and-mouth disease virus
Goat pox virus
Japanese encephalitis virus
Lumpy skin disease virus
Malignant catarrhal fever virus (Alcelaphine herpesvirus type 1)
Menangle virus
Mycoplasma capricolum subspecies capripneumoniae (contagious caprine pleuropneumonia)
Mycoplasma mycoides subspecies mycoides small colony (MmmSC) (contagious bovine pleuropneumonia)
Peste des petits ruminants virus
Rinderpest virus
Sheep pox virus
Swine vesicular disease virus
Vesicular stomatitis virus (exotic): Indiana subtypes VSV-IN2, VSV-IN3
Virulent Newcastle disease virus1

USDA PLANT PROTECTION AND QUARANTINE (PPQ) SELECT AGENTS AND TOXINS

Peronosclerospora philippinensis (Peronosclerospora sacchari)
Phoma glycinicola (formerly Pyrenochaeta glycines)
Ralstonia solanacearum race 3, biovar 2
Rathayibacter toxicus
Sclerophthora rayssiae var zeae
Synchytrium endobioticum
Xanthomonas oryzae
Xylella fastidiosa (citrus variegated chlorosis strain)

1 A virulent Newcastle disease virus (avian paramyxovirus serotype 1) has an intracerebral pathogenicity index in day-old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus. A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus.

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